Power plants – Internal combustion engine with treatment or handling of... – Methods
Patent
1997-09-02
1999-12-21
Look, Edward K.
Power plants
Internal combustion engine with treatment or handling of...
Methods
60276, 60297, 60300, 60303, 422182, F01N 300
Patent
active
060033053
ABSTRACT:
A process is provided for preparing oxymorphone from morphine by:
(1) reacting morphine with (1a) an acyl halide or anhydride to form 3-acylmorphine, or (1b) reacting morphine with benzyl-halide to form 3-benzylmorphine;
(2) Oxidizing the 6-hydroxy group of the 3-acyl or 3-benzylmorphine so as to form the corresponding 3-acyl or 3-benzylmorphinone; and thereafter either by (3a) or (3b):
(3a) introducing a .beta.-oriented hydroxy group at the 14-position of the 3-acyl- or 3-benzyl-morphinone with aqueous hydrogen peroxide and an acid at a temperature of about 15.degree. to about 70.degree. C. to form the 3-acyl or 3-benzyl-14-hydroxymorphinone;
(3b) acylating the 3-acyl or 3-benzyl-morphinone with an acylating agent so as to form the dienol acylate followed by oxidizing the dienol acetate to the corresponding 3-acyl or 3-benzyl-14 -hydroxymorphinone;
(4) hydrogenating the 3-acyl-14-hydroxymorphinone with a catalyst so as to form the 3-acyloxymorphone;
(5) hydrolyzing the 3-acyl-oxymorphone with aqueous acidic or basic solution to form oxymorphone;
(6) hydrogenating the 3-benzyl-14-hydroxymorphinone with a catalyst so as to form oxymorphone.
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Barkdoll Michael P.
Edgar Bradley L.
Holst Mark R.
Martin Richard J.
Stilger John D.
Look Edward K.
Thermatrix Inc.
Tran Binh
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