Method of reducing immunogenicity and inducing immunologic toler

Details Method of reducing immunogenicity and inducing immunologic toler Method of reducing immunogenicity and inducing immunologic toler

1988-12-21

1991-03-12

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

128898, 600 36, A61N 130, A61F 204

Patent

active

049989316

ABSTRACT:
The immunogenicity of transfused or transplanted, allogeneic tissue is reduced by either directly exposing the tissue to ultraviolet (UV) irradiation prior to administering the tissue to the recipient or by inducing a state of tolerance in the recipient to non-UV or UV-irradiated allogeneic tissue by prior exposure to UV-irradiated allogeneic tissue.

REFERENCES:
patent: 4321918 (1982-03-01), Clark, II
patent: 4321919 (1982-03-01), Edelson
patent: 4428744 (1984-01-01), Edelson
patent: 4464166 (1984-08-01), Edelson
patent: 4608255 (1986-08-01), Kahn et al.
patent: 4861704 (1989-08-01), Reemtsma et al.
M. A. Hardy, H. T. Lau, C. Weber, and K. Reemtsma, "Pancreatic Islet Transplantation: Immuno-Alteration with Ultraviolet Irradiation", World J. Surg., 8(2):207-213, Apr., 1984.
H. Lau, K. Reemtsma, and M. A. Hardy, "The Use of Direct Ultraviolet Irradiation and Cyclosporine in Facilitating Indefinite Pancreatic Islet of Allograft Acceptance", Transplantation 38(6):566-569, Dec. 1984.
H. Lau, K. Reemtsma, and M. A. Hardy, "Prolongation of Rat Islet Allograft Survival by Direct Ultraviolet Irradiation of the Graft", Science 223:607-609, Feb. 10, 1984.
J. D. Balshi, M.D., J. W. Francford, M.D., and L. J. Perloff, M.D., "The Influence of Ultraviolet Irradiation on the Blood Transfusion Effect", Surgery, 98(2):243-250, Aug., 1985.
M. A. Hardy, H. Lau, and K. Reemtsma, "Prolongation of Rat Islet Allografts with the use of Ultraviolet Irradiation, Without Immunosuppression", Transplantation Proceedings, 16(3):865-869, 1984.
M. A. Hardy, H. Lau, C. Weber, and K. Reemtsma, "Induction of Graft Acceptance by Ultraviolet Irradiation of Donor Tissue", Ann. Surg., 200(4):441-450, 1984.
H. Lau et al., Eur. Sur. Res., 16(suppl. 1):42-43, 1984.
H. Lau et al., "Pancreatic Islet Allograft Prolongation by Donor-Specific Blood Transfusions Treated with Ultraviolet Irradiation", Science, 221:754-755, 1983.
R. D. Granstein, "Epidermal I-J-Bearing Cells are Responsible for Transferable Suppressor Cell Generation After Immunization of Mice with Ultraviolet Radiation-Treated Epidermal Cells", J. of Investigative Dermatology, 84(3):206-209, 1985.
M. L. Kripke, "Immunological Unresponsiveness Induced by Ultraviolet Radiation", Immunological Reviews 80:86-101, 1984.
L. M. Slater et al., "Dissimilar Effects of Ultraviolet Light on HLA-D and HLA-DR Antigens", Tissue Antigens, 15:431-435, 1980.
R. M. Steinman and M. C. Nussenzweig, "Dentritic Cells: Features and Functions", Immunological Rev., 53:127-147, 1980.
S. J. Slichter, H. J. Deeg, M. Kennedy, "Prevention of Platelet (PLT) Alloimmunizations: Use of Cyclosporine-Loaded (C-L) or UV Irradiated Donor Plts.", Am. Soc. of Hematology, 26 Annual Meeting, Dec. 1-4, 1984.

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