Method of reducing hypertension by administering flavanol...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing

Reexamination Certificate

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Reexamination Certificate

active

07833962

ABSTRACT:
The present invention relates to use of a plant which has been modified to produce increased levels of flavonol glucosides, or an extract thereof containing flavonol glucosides, in reducing hypertension in a mammal.

REFERENCES:
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Duarte et al, British Journal of Pharmacology, vol. 133, p. 117-124, 2001.
Bovy, et al., “High-Flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and CI”, plant cell, vol. 14, No. 10, Oct. 2002, pp. 2509-2526, XP002295919.
Verhoeyen, et al., “Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway”, J. Exp Botany (2002), 377:2099-2106.
Duarte, et al., “Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats”, British Journal of Pharmacology, 2001 United Kingdom, vol. 133, No. 1, 2001, pp. 117-124, XP002295921.
Muir, et al., “Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols”, Nature Biotechnology, vol. 19, No. 5, May 2001, pp. 470-474. XP002295920.
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GB Search Report GB 0317985.0 dated Nov. 25, 2003.

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