Method of reducing blood sugar levels using a hypoglycemic agent

Details Method of reducing blood sugar levels using a hypoglycemic agent Method of reducing blood sugar levels using a hypoglycemic agent

1989-09-21

1993-08-31

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, A61K 3702

Patent

active

052409112

ABSTRACT:
Pharmaceutical compositions containing the polypeptides BUF-3, BUF-4 and BUF-5 have hypoglycemic activity. BUF-3 is a homodimer of monomer A shown in FIG. 1. The monomer has a molecular weight of 16.+-.1 kd. BUF-4 is a heterodimer of monomer A and monomer B (FIG. 2). These products can be produced by cell culture of malignant leukemia cells or by recombinant DNA engineering.

REFERENCES:
patent: 4740587 (1988-04-01), Ling et al.
Mason et al. "Complementary DNA Sequences of Ovarian Follicular Fluid Inhibin Show Precursor Structure and Homology with TGF-B" Nature 318 pp. 659-663 (1985).

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