Method of reducing adipocyte growth in a subject in need...

Details Method of reducing adipocyte growth in a subject in need... Method of reducing adipocyte growth in a subject in need...

2008-09-02

2008-09-02

Landsman, Robert (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C530S324000, C514S909000

Reexamination Certificate

active

10898490

ABSTRACT:
Disclosed is a method of using synthetic analogs of natriuretic peptides and more particularly to synthetic linear peptide analogs as pro-lipolytic, as anti-obesity agents, and as intermediates for or modulators of such useful compounds. Inhibitors to nprC are disclosed to treat or prevent adipose accumulation in mammals.

REFERENCES:
Matsukawa et al., Proc. Natl. Acad. Sci. USA 96: 7403-7408, 1999.
Sun et al., Am J. Phys. Renal Phys. 282 : 220-227, 2002.
Campese et al Hypertension 28: 335-340, 1996.
Rebbeck et al., Nature Review Genetics 5: 589-97, 2004.
Flier et al., “Leptin Expression and action: New experimental paradigms”, PNAS, vol. 94, pp. 4242-4245 (Apr. 1997).
Samad et al., “Tissue factor gene expression in the adipose tissues of obese mice”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 7591-7596 (Jun. 1998).

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