Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Processes of making – purifying or recovering
Patent
1975-08-12
1977-05-10
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Processes of making, purifying or recovering
A61K 3500
Patent
active
040228860
ABSTRACT:
Mycoheptin, an antifungal antibiotic, is obtained by extracting the antibiotic from the mycelium with a 65 to 80-percent aqueous solution of isopropanol which contains from 1 to 10 percent by weight of calcium chloride and 10 to 15 percent by weight of methylene chloride, precipitating the antibiotic, washing it with aqueous isopropanol, reprecipitating it from a dimethylformamide solution with water, and treating the product with a 20 to 50-percent aqueous solution of n-propanol containing from 0.2 to 0.5 percent by weight of sodium hexametaphosphate.
The novel extracting and reprecipitating agents employed in the process of this invention result in a yield which is 1.5-times that of known methods of mycoheptine recovery from the mycelium as well as in a higher quality of the desired product.
REFERENCES:
chemical Abstracts, vol. 70, p. 210, 46191m, 1969.
Alexeeva Ljudmila Evgenievna
Bashkovich Alexandr Pavlovich
Etingov Evgeny Davidovich
Kulbakh Valter Osvaldovich
Lokhina Nadezhda Dmitrievna
Meyers Albert T.
Stephens Daren M.
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