Method of raising antibodies against E. coli of the family CS4-C

Details Method of raising antibodies against E. coli of the family CS4-C Method of raising antibodies against E. coli of the family CS4-C

1995-06-02

1999-06-22

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 4241941, 4242341, 4242421, 4241691, 4242571, 4241851, 530300, 530333, 530324, 514 12, 514 62, 514 2, 514867, A61K 39108, A61K 3900, A61K 3800, C07K 200

Patent

active

059141140

ABSTRACT:
A consensus poptide of 36 amino acids has been designed which acts as an immunogen raising antibodies against the proteins of all members of the E. coli family CS4-CFA/1. While the N-terminus of members of this family of organisms shows a high degree of identity, the remainder of the sequence of the proteins shows much less homology across the strains. The region of the protein represented in the subunit encompasses known linear B- and T-cell epitopes of CFA/I. The consensus peptide has a high level of homology to strains bearing six different colonization factors. The consensus peptide is of the formula:

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