Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Anti-idiotypic
Patent
1996-01-19
1998-04-28
Loring, Susan A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Anti-idiotypic
4241491, 5303872, 5303883, 5303894, 514 14, A61K 39395, A61K 3803, C07K 1608, C07K 1642
Patent
active
057441359
ABSTRACT:
The invention comprises an anti-idiotypic antibody designated 2F10 and permitted variants thereof, which have antigenic properties similar to the group specific "a" determinant of human hepatitis B surface antigen HBsAg and have at least partial but not complete homology with such surface antigen. The invention further comprises a peptide having a chain comprising the amino acid residues Ala Val Tyr Tyr Cys Thr Arg Gly Tyr His Gly Ser Ser Leu Tyr and permitted variants thereof, which, like 2F10, have antigenic properties similar to the group specific "a" determinant of human hepatitis B surface antigen HBsAg and have at least partial, but not complete, homology with said surface antigen. The amino acid sequence is found in and forms a part of 2F10. The shorter peptide chain comprising the amino acid residues Gly Tyr His Gly Ser Ser Leu Tyr and permitted variants thereof, also have antigenic properties similar to the group specific "a" determinant of human hepatitis B surface antigen HBsAg and have at least partial, but not complete, homology with said surface antigen.
REFERENCES:
patent: 4778761 (1988-10-01), Miyanohara et al.
patent: 4803164 (1989-02-01), Hitzeman et al.
Wands et al., "Identification and Transmission of Hepatitis B virus-related variants", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 6608-6612, Sep. 1986.
"HBaAG Positive Reactivity in Man Not Due to Hepatitis B Virus", The Lancet, Dec. 12, 1987.
Neurath et al., "Toleration of Amino Acid Substitutions within Hepatitis B Virus Envelope Protein Epitopes Estabilished by Peptide Replacement Set Analysis. I. Region S(139-147)" Peptide Res.vol. 3, No. 3 (1990).
Lai et al., "Hepatitis B virus DNA in the Serum ofSardinian Blood Donors Negative for the Hepatitis B Surface Antigen", Blood, Jan. 1989, 73(1) pp. 17-19.
Carman et al., "Vaccine-induced Escape Mutant of Hepatitis B Virus", The Lancet, vol. 336, pp. 325-329 (Aug. 1990).
Egea et al., "The Cellular Basis for Lack of Antibody Response to Hepatitis B Baccine in Humans", Exp. Med., vol. 173, pp. 531-538 (Mar. 1991).
Cupps et al., "In Vitro Immune Responses to Hepatitis B Surface Antigens S and preS2 during Acute Infection by Hepatitis B Virus in Humans", The Journal of Infectious Disdease, 161, pp. 412-419 (1990).
Cupps et al., "In Vitro Immune Responses to Hepatitis B Surface Antigen (Pre-S2 and S) Following Remote Infection by Hepatitis B Virus in Humans", Journal of Clinical Immunology, vol. 9, No. 3, (1989).
Jin et al., "Human T Cell Response to the Surface Antigen of Hepatitis B Virus (HBsAg)", Journal of Experimental Medicine, vol. 168, pp.293-306 (1988).
Jin et al., "An Oligoclonal Human T-Cell Line Specific for HBsAg is Restricted to MHC Class I Antigens and Responds to Soluble Antigen and to Endogenous HBsAg" Viral Hepatitis and Liver Disease, pp. 678-683 (1988).
Chang et al., "In Vitro Response to HBsAG of Peripheral Blood Lymphocytes from Recipients of Hepatitis B Vaccine", Hepatology, vol. 4, No. 5, pp. 824-829(1984).
Celis et al., Recognition of Hepatitis B Surface Antigen by Human T Lymphocytes The Journal of Immunology, vol. 140, pp. 1808-1815, No. 6 (1988).
Celis et al., "Hepatitis B Virus-Reactive Human T Lymphocyte Clones: Antigen Specificity and Helper Function for Antibody Synthesis", The Journal of Immunol. vol. 132, No. 3, (1984).
Pride et al., "Stimulation of Murine and Human HBsAG Specific B and T Cells by an Internal image anti-Id", pp. 263-270 (1990).
Brown et al., "Affinity of Antibody Responses in Man to Hepatitis B Vaccine determined with Synthetic Peptides", Lancet, Jul. 1984, 29(8396) pp. 184-187.
Okamoto et al., "The Loss of Subtypic Determinants in Alleles, d/y or w/r, on Hepatitis B Surface Antigen", Molecular Immunol. vol. 26, No. 2, pp. 197-205, (1989).
Brown et al., "Determination of the Affinity of Antibodies to Hepatitis B Surface Antigen in Human Sera", Journal of Immuno. Methods, 72, pp. 41-48 (1984).
Delpeyroux et al., "Insertions in the Hepatitis B Surface Antigen", J. Mol. Biol. 195, pp. 343-350 (1987).
Delpeyroux et al., "Presentation and Immunogenicity of the Hepatitis B Surface Antigen and a Poliovirus Neutralization Antigen on Mixed Empty Envelope Particles" Journal of Virology, pp. 1836-1839, (1988).
Rajadhyaksha et al., "Delineation of the Minimal Hepatitis B Surface antigen-specific B-and T-cell epitope contained within an anti-idiotype-derived pentadecapeptide", Proc. Natl. Acad. Sci. USA, vol. 92, pp. 1575-1579, Feb. 1995.
Rajadhyaksha et al., "Differential antigen presentation of hepatitis B surface antigen on cell membranes of responder and nonresponder mice", Tissue Antigens, 45: 188-196 (1995).
Pride et al., "Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide", Proc. Natl. Acad. Sci. USA, vol. 89, pp. 11900-11904, Dec. 1992.
Thanavala et al., "Immunoglobulin Idiotypes and Anti-Idiotypes", Immunochemistry, pp. 69-91 (1994).
Rajadhyaksha et al., "Immunological evaluation of three generations of anti-idiotype vaccine: study of B and T cell responses following priming anti-idiotype peptide and its MAP structure", Vaccine, vol. 13, No. 15, pp. 1421-1426 (1995).
Thanavala et al., "Immunogenicity of transgenic plant-derived hepatitis B surface antigen", Proc. Natl. Acad. Sci. USA, vol. 92, pp. 3358-3361, Apr. 1995.
Yang et al., "A Comparison of the Antibody and T Cell Response Elicited by Internal Image and Noninternal Image Anti-idiotypes", Clinical Immuology and Immunopathology, vol. 75, No. 2, pp. 154-158, May 1995.
Pride Michael
Roitt Ivan
Thakur Arvind
Thanavala Yasmin
Dunn Michael L.
Health Research , Inc.
Loring Susan A.
University College London
LandOfFree
Method of raising an immune response with an anti-idiotypic anti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of raising an immune response with an anti-idiotypic anti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of raising an immune response with an anti-idiotypic anti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1529834