Method of radiolabeling chelating compounds comprising sulfur at

Details Method of radiolabeling chelating compounds comprising sulfur at Method of radiolabeling chelating compounds comprising sulfur at

1988-07-01

1991-06-04

Stoll, Robert L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 11, 534 14, 534 15, 424 11, C07F 1900, C07F 1300, A61K 4300

Patent

active

050215566

ABSTRACT:
Chelating compounds which comprise one or more sulfur atoms and are to be radiolabeled with metal radionuclides to form the corresponding chelates are disclosed. The chelating compounds comprise thioacetal or hemithioacetal sulfur protecting groups which are displaced during the radiolabeling reaction, which is conducted at acidic pH, such that bonds form between said sulfur atoms and said radionuclide. The resulting metal radionuclide chelates have diagnostic and therapeutic medical uses.

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