Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In aerosol – fine spray – effervescent – pressurized fluid,...
Reexamination Certificate
1998-04-06
2001-01-09
Jones, Dameron (Department: 1616)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In aerosol, fine spray, effervescent, pressurized fluid,...
C424S001330, C424S001370, C424S009400, C424S001110
Reexamination Certificate
active
06171575
ABSTRACT:
BACKGROUND OF THE INVENTION
The olfactory system possesses certain peculiarities: (i) The olfactory mucosa plugs the cribriform openings of the skull base; and (ii) The olfactory receptor cells connect themselves to neural cells in the olfactory bulb by passing their nerve fibers through these openings (
1
). Therefore, this mucosa functions as the nose-brain barrier (hereinafter designated as NBB). NBB's disintegration may result from a variety of pathological changes (categories I and II), leading to penetration of toxic chemicals and microorganisms into the brain system. Category I: Loss of the plugging integrity: (a) mucosal inflammation; and (b) degeneration and/or loss of the constituent olfactory receptor cells, supporting cells or basal cells. Category II: Morbid afferent transmission through the olfactory nerve fibers: (c) transmission of toxic chemicals; and possibly (d) transmission of viral particles.
The NBB's integrity may be of crucial importance in the etiology of influenzal encephalitis, Alzheimer's disease (Roberts 1986; Perl and Good 1987; Matsushima 1991; Yamagishi et al. 1992), and other diseases. The present study is the first attempt to develop a novel radioisotopic technique for detection of NBB disintegration.
It may help developing novel medicine for anesthesia and treatment of selected brain diseases.
REFERENCES:
patent: 5725852 (1998-03-01), Igari et al.
Author: Shinichi Okuyama, Title: “The First Attempt at Radioisotopic evaluation of the Intergrity of the Nose-Brain Barrier” Apr. 18, 1997, Life Sciences, vol. 60, No. 21, pp. 1881-1884.
Author: Brian J. Balin et al., Title: “Avenues for Entry of Peripherally Administered Protein to The Central Nervous System in Mouse, Rat, and Squirrel, Monkey”,The Journal of Comparative Neurology,vol. 251, 1986, pp. 260-280.
Author: Richard M. Kream et al., Title: “Olfactory Marker Protein: Turnover and Transport in Normal”The Journal of Neuroscience,vol. 4, No. 3, and Regenerating Neurons, Mar. 1984, pp. 868-879.
Author: Eigi Matsushima, “Olfactory Dysfunction of Dementia of Alzheimer Type”,J. Yonago Med. Assoc.,vol. 42, 1991, pp. 120-127.
Author: Daniel P. Perl et al., “Uptake of Aluminium into Central Nervous System Along Nasal-Olfactory Pathways”The Lancet,1987, pp. 1028.
Author: Eugene Roberts, “Alzheimer's Disease May Begin in the Nose and May Be Caused by Aluminosilicates”,Neurobiology of Aging,vol. 7, 1986, pp. 561-567.
Author: A.H. Tomlinson et al., “Herpes Simplexencephalitis”,Journal of the Neurological Sciences,vol. 60, 1983, pp. 473-484.
Author: M. Yamagishi et al., “Definitive Diagnosis of Alzheimer's Disease Using Olfactory Mucosal Biopsy”,Proceedings of Symposium on Testing and Olfactory Functions,1992, pp. 365-368.
LandOfFree
Method of radioisotopic assessment of the integrity and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of radioisotopic assessment of the integrity and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of radioisotopic assessment of the integrity and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2529557