Method of purifying tpa or plasminogen activator using a tripept

Details Method of purifying tpa or plasminogen activator using a tripept Method of purifying tpa or plasminogen activator using a tripept

1990-04-17

1992-08-25

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 435215, C12N 964, C12N 948, C12N 972

Patent

active

051418622

ABSTRACT:
A method for purifying tPA or a plasminogen activator having an active site resembling that of tPA from an impure solution thereof which comprises contacting the impure solution with a solid support having bound thereto a tripeptide of the formula: -X-Y-argininal, wherein X and Y are amino acids selected from the group consisting of pro, phe, trp and tyr. The method is also used with a tripeptide of the formula: -phe-Y-argininal, wherein Y is selected from the group consisting of phe, pro, trp, tyr, val, ile and glu(PEA).

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Patel et al., Biochem Biophys Acta, 748:321-330 (1983).

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