Method of purifying bioactive substances by biospecific adsorpti

Details Method of purifying bioactive substances by biospecific adsorpti Method of purifying bioactive substances by biospecific adsorpti

1988-10-04

1990-05-15

Garvin, Patrick P.

Catalyst, solid sorbent, or support therefor: product or process

Biospecific material, or produced by enzyme or microorganism

502401, B01J 2022, B01J 3736

Patent

active

049258184

ABSTRACT:
A ligand specific to a bioactive substance to be purified is fixed, via a connecting silane, to a mineral particulate carrier chosen from among SiO.sub.2, Al.sub.2 O.sub.3, ZrO.sub.2 and TiO.sub.2, the particles of the carrier being submicronic, non-porous and having a large specific surface. The carrier is contacted with an aqueous extract containing inter alia the bioactive substances, for the time required for the substance to become specifically fixed to the carrier. The carrier is then separated and the desired bioactive substance is isolated by desorption.

REFERENCES:
patent: 3652761 (1972-03-01), Weetall
Roy, Asit K., and Roy, Sujata, "Preparation of a High Flow Packing Material (Silica Based) for High Performance Affinity Chromatography of Proteins", AMF Specialty Materials Group, Meriden, Conn., USA, Academic Press, Inc. (1983), pp. 257-258.

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