Method of purifying 2',3'-dideoxynucleosides

Details Method of purifying 2',3'-dideoxynucleosides Method of purifying 2',3'-dideoxynucleosides

1993-06-16

1995-09-19

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 282, 536 2714, C07H 19173

Patent

active

054516714

ABSTRACT:
A crude 2',3'-dideoxynucleoside compound is purified by extracting with an organic solvent, or crystallizing, the 2',3'-dideoxynucleoside compound from a basic aqueous solution having a pH of not less than 12 containing the same. In another embodiment of purification a basic aqueous solution having a pH of not less than 11 of a crude 2',3'-dideoxynucleoside derivative is brought into contact with a nonpolar porous resin, whereby the derivative is adsorbed on the resin, and then the thus adsorbed derivative is desorbed with an aqueous alcoholic solution.
2',3'-Dideoxynucleoside compounds which have utility as anti-AIDS drugs or anti-virus drugs can be isolated and purified in high purity and in high yield from their crude products containing impurities.

REFERENCES:
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 4835104 (1989-05-01), Yokozeki et al.
patent: 4962193 (1990-10-01), Yokozeki et al.
Honig et al. eds., The Van Nostrand Chemist's Dictionary, D. Van Nostrand Co. Inc., New York, N.Y., 1953, p. 620.
Budavari et al. eds., The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 11th Ed., Merck & Co, Inc., Rahway, N.J. ,1989, entry numbers 3090, 141, 3092, 4805.
Acheson, An Introduction to the Chemistry of Heterocyclic Compounds, 2nd Ed., Interscience Publishers, New York, N.Y., 1967, p. 302, 354-355.
Japanese Laid-Open Application No: 1-198496, Apr. 17, 1989.
Japanese Laid-Open Application No: 1-175990, Jul. 12, 1989.
Japanese Laid-Open Application No: 1-165390, Jun. 29, 1989.
Japanese Laid-Open Application No: 1-175991, Jul. 12, 1989.
The Journal of Organic Chemistry, vol. 54, Sep. 29, 1989, No. 20, Mansuri et al, 43,4780.
Journal of Medicinal Chemistry, vol. 33, No. 6, Amrican Chemical Society, Chu et al. 33,1553.
Tetrahedron Letters, vol. 25, No. 4. pp. 367-370, (1984), Robins et al, 25,367.
Journal of the American Chemical Society, vol. 88, Apr. 5, 1966, No. 7, McCarthy et al, 88,1549.

Affiliated with

Also associated with

Rating

Method of purifying 2',3'-dideoxynucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of purifying 2',3'-dideoxynucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of purifying 2',3'-dideoxynucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1829207