Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1989-10-11
1991-09-10
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530412, 530415, 530416, 530424, C07K 302, C07K 322, C07K 328
Patent
active
050475100
ABSTRACT:
The present invention relates to improved methods for purifying TGF-beta so as to obtain such in high yields. The process steps consist of acid-ethanol extracting platelets, cation exchange separation, and hydrophobic separation.
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Sofer et al., Bio Techniques, Nov./Dec. 1983, pp. 198-203.
Bonnerjea et al., Bio Technology, vol. 4, 1986, pp. 954-958.
Seyedin et al., JBC 261, 1986, pp. 5693-5695.
Marquardt et al., PNAS 80, 1983, pp. 4684-4688.
Twardzik et al., PNAS 82, 1985, pp. 5300-5304.
Cheifetz et al., Cell, vol. 48, 1987, pp. 409-415.
Frolik et al., Am Soc Biol Chem 74th Meeting, 1983, #440.
Bio-Rad Bulletin 1153.
Cone James L.
DeLarco Joseph E.
Moezie F. T.
Ostuka Pharmaceutical Co. Ltd.
Rozycki Andrew G.
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