Method of pulsatile drug infusion

Details Method of pulsatile drug infusion Method of pulsatile drug infusion

1992-12-21

1995-04-04

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

514 21, 514169, 514727, A61K 908

Patent

active

054035902

ABSTRACT:
A method of pulsatile infusion of a drug or other therapeutic agent is described. The pulsatile infusion method minimizes tachyphylaxis, while enabling the target cell, tissue, or organ to benefit from the administered drug or other therapeutic agent. The drug or other therapeutic agent, an agonist or antagonist for a molecule of the receptor system, is administered in a succession of at least two pulses. The pulses have a selected amplitude and duration so that the binding affinity of the receptor system molecule is decreased by a predetermined amount in response to each pulse. This predetermined amount is less than the difference between the maximum binding affinity of the receptor system molecule, when it is not exposed to either the agonist or antagonist, and its minimum binding affinity for the agonist or antagonist, when it is continuously exposed to the agonist or antagonist. The pulses are spaced apart by a selected interpulse period wherein the binding affinity of the receptor system molecule increases to the maximum value.

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