Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-01-12
2001-02-13
Jarvis, William R. A. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
06187791
ABSTRACT:
SUMMARY OF THE INVENTION
The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of Formula (1)
wherein
R
1
is hydrogen or hydroxy;
R
2
is hydrogen;
or R
1
and R
2
taken together form a second bond between
the carbon atoms bearing R
1
and R
2;
n is an integer of from 1 to 5;
R
3
is —COOH or —COOalkyl wherein the alkyl moiety has
from 1 to 6 carbon atoms and is straight or branched;
each of A and B is hydrogen or hydroxy with the proviso
that at least one of A or B is hydrogen;
or a pharmaceutically acceptable salt and individual isomers thereof.
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Eller Mark G.
McNutt Bruce E.
Okerholm Richard A.
Woodward James K.
Jarvis William R. A.
Merrell Pharmaceuticals Inc.
Pillsbury Madison & Sutro LLP
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