Method of providing a substrate with a bio-active/biocompatible

Details Method of providing a substrate with a bio-active/biocompatible Method of providing a substrate with a bio-active/biocompatible

1997-06-18

1999-02-09

Dudash, Diana

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Analysis, diagnosis, measuring, or testing product

427 213, 427 228, 427 23, 427 231, 427333, B05D 310, B05D 300, A61L 3300

Patent

active

058691278

ABSTRACT:
Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.

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