Method of protection of the carboxy groups in the chemistry of .

Details Method of protection of the carboxy groups in the chemistry of . Method of protection of the carboxy groups in the chemistry of .

1989-04-04

1992-01-07

Elmore, Carolyn

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 43, 435 44, 435 45, 435 46, 435 48, 435 49, 435 50, 435 51, 435230, C12P 3700, C12P 3500

Patent

active

050791460

ABSTRACT:
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of .beta.-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetoxy-methyl ester, which is then removed by an enzymatic route by means of penicillinacylase.
In particular, if the .beta.-lactam compound also bears a phenyl-acetamidic substitutent, this latter is simultaneously hydrolysed during the same step of removal of the carboxy function protecting group.

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patent: 3528965 (1970-09-01), Cole et al.
patent: 3880713 (1975-04-01), Fleming et al.
patent: 3945888 (1976-03-01), Takahashi et al.
patent: 3972774 (1974-08-01), Brannon et al.
patent: 4413056 (1983-11-01), Chester et al.

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