Method of protecting mammals against neuronal damage resulting f

Details Method of protecting mammals against neuronal damage resulting f Method of protecting mammals against neuronal damage resulting f

1989-11-30

1991-04-23

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514921, 514452, 514906, 514930, A61K 3140

Patent

active

050100963

ABSTRACT:
The use of a compound of formula (I) or a physiologically acceptable salt or hydrate thereof in the treatment, relief or prevention of the effects of cerebral ischaemia ##STR1## Compounds of formula (I) are described in UK Published Patent Application No. 2157691A.
The compounds of formula (I) have been found to protect mammals, including man, against neuronal damage resulting from cerebral ischaemia.
The preferred compound for use in this indication is (.+-.)-trans-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]-benzodioxino[2,3-c]- pyrrole (formula (I), R=H, R.sup.1 =F, R.sup.2 =H), especially in the form of its hydrochloride salt.

REFERENCES:
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patent: 4769367 (1988-09-01), Cherry et al.
patent: 4880801 (1989-11-01), Kitchin et al.
Gustafson et al., Cerebrovascular Diseases; 1989, 117.
Gustafson et al., J. Cerebral Flow Metab., 1989, 1.
C. A. Halliday et al., Br. J. Pharmacol., 1989, 95 (Suppl.), 857P.
C. A. Halliday et al., Br. J. Pharmacol., 1988, 95 (Suppl.), 751P.
R. Seitelberger et al., Circ. Res., 1988, 62(3), 436.

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