Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-12-26
2006-12-26
Li, Q. Janice (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S093100, C435S254200
Reexamination Certificate
active
07153839
ABSTRACT:
The present invention concerns a compound consisting of RNA, in particular RNA extracted from yeast, a pharmaceutical composition comprising such RNA and a method for the treatment of inflammatory and inflammatory-related disorders comprising administering to a patient in need of such treatment a pharmaceutical composition comprising an amount effective to ameliorate the symptoms of inflammation or inflammatory-related disorder of ribonucleic acid and a pharmaceutically acceptable vehicle, carrier, or diluent. The exogenous yeast RNA used in the present invention has a pronounced membrane-stabilizing action in a wide range of concentrations. At the same time, yeast RNA normalizes metabolism of arachidonic acid and levels of its key metabolites, thromboxane and leukotriene. Its anti-inflammatory action is accompanied by normalization of the activity of NO-synthetase and anti-oxidant activity.
REFERENCES:
patent: 3615654 (1971-10-01), Yaichi et al.
patent: 4303680 (1981-12-01), Tanekawa et al.
patent: 5712256 (1998-01-01), Kulkarni et al.
patent: 6737271 (2004-05-01), Tkachuk
patent: 94-02595 (1994-02-01), None
Sabatino et al, PNAS Nov. 2000;97:13294-99.
Wills, Nutrition 1991;7:323-7.
Mehanna et al, Curr Med Chem 2001;8:79-88.
Rund et al, 2001;38:343-9.
Gardner et al, Adv Intern Med 1987;32:155-76.
Lan et al, Science 1998;280:1593-6.
Sullenger, Gene Ther 1999;6:461-2.
Mitchell et al, Curr Opin Mol Ther Apr 2000;2:176-181.
Qui et al, Gene Ther 1996; 3:262-8.
Sved, Can J Biochem 1965;43:949-58.
Perederii V G et al.: “Pathogenetic Role of RNA in Chronic Inflammatory and Ulcerative Diseases of the Digestive Tract”,Vrachebnoe Delo, No. 1, 1988, pp. 21-24, XP009030616, ISSN: 0049-6804.
Rudolph F B et al.: “Role of RNA as a dietary source of pyrimidines and purines in immune function”,Nutrition(Burbank, Los Angeles County, Calif.) Jan.-Feb. 1990, vol. 6, No. 1, Jan. 1990, pp. 45-52; disc, XP009030648, ISSN: 0899-9007.
Iyer et al., Absolute mRNA levels and transcriptional initiation rates inSaccharomyces cerevisiae, May 1996, Proc. Natl. Acad. Sci., vol. 93, pp. 5208-5212.
Prokopenko, L.H., Siplivaya, L.E., Erythrocytes as modulators of immunologic reactions, Uspekhi Phiziologicheskikh Nauk., V.23, N.4, p. 89-106, 1992.
Karalnik, B.V., Erythrocytes, their receptors, and immunity, Uspekhi Sovremennoy Biologii., V.112, N.1, P. 52-61, 1992.
Kordyum, V.A., Kirilova, V.S., Likhachova, L.I., Biological action of exogenous nucleic acids, Visnyk ASC USSR, V.41, N.6, p. 67-78, 1977.
Courtright, L.J., Kuzell, W.C., Sparing effect of neurological deficit and trauma on the course of adjuvant arthritis in the rat,Ann, rheum, dis., N.24, p. 360-367, 1965.
Terskov, A., Gitelzon, I., The method of chemical (acid) erythrograms, Biophisika V.1, N.20, 1956.
Kosaka, H., Harada, N., Watanabe, M., Yoshihara, H., Katsuki, Y., Shiga, T., Synergistic stimulation of nitric oxide 1 and tumor necrosis factor, Biochemical and Biophysical Research Communications, V.189, N.1, p. 392-397, 1992.
Huot, A.E., Kruszyna, H., Smith, R.P., Hacker, M.P., Formation of nitric oxide hemoglobin in erythrocytes co-cultured with alveolar macrophages taken from bleomycin treated rats, Biochemical and Biophysical Research Communications, V.182, N.1, p. 151-157, 1992.
Sato, Y., Kamo, S., Takahashi, T., Suzuki, Y., Mechanism of free radical-induced hemolysis of human erythrocytes: hemolysis by water-soluble radical initiator, Biochemistry, N.34, p. 8940-8949, 1995.
Eich, R.F., Li, T., Lemon, D.D., Doherty, D.H., Curry, S.R., Aitken, J.F., Matthews, A.J., Johnson, K.A., Smith, R.D., Phillips, G.N., Olsen, J.S., Mechanism of NO-induced oxidation of myoglobin and hemoglobin, Biochemistry, N.35, p. 6976-6983, 1996.
Mueller, B., Maass, B., Krause, W., Witt, W., Limitation of myocardial unoerfused area and necrotic zone 24 hours and 7 days after coronary artery ligation in rats by the stable prostacyclin analogue iloprost, Prostaglandins Leukotrienes and Medicine, N.21, p. 331-340, 1986.
Khawaja, J., Interaction of ribosomes and ribosomal subparticles with endoplasmic reticulum membranesin vitro: Effect of spermine and magnesium, Biochimica et Biophisica Acta, N.254, p. 117-128, 1971.
Cundliffe, E., Intracellular distribution of ribosomes and polyribosomes inbacillus megaterium, Mol. Biol., N.52, p. 467-481, 1970.
Hibbs, J.B., Taintor, R.R., Vavrin, Z., Rachlin, E.M., Nitric oxide: A cytotoxic activated macrophage effector molecule, Biochemical and Biophysical Research Communications, V.157, N.1, p. 87-94, 1988.
Scott-Burden,T., Hawtrey, A.O., Preparation of ribosome-free membranes from rat liver microsomes by means of lithium chloride, Biochem.J., N.115, p. 1063-1069, 1969.
Mainwaring, W.I.P., The effect of age on protein synthesis in mouse liver, Biochem.J., N.113, p. 869-878, 1969.
Yan, L., Vandivier, W., Suffredini, A.F., Danner, R.L., Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity, The Journal of Immunology, p. 1825-1834, 1994.
Arnet, U.A., McMillan, A., Dinnerman, J.L., Ballerman, B., Lowenstein, C., Regulation of endothelial nitric-oxide synthase during hypoxia, Journal of Biological Chemistry, V.271, N.25, p. 15069-15073, 1996.
Balligand, J.L., Kobzik, L., Han, X., Kaye, D.M., Belhassen, L., O'Hara, D.S., Kelly, R.A., Smith, T.W., Michel, T., Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes, The Journal of Biological Chemistry, V.270, N.24, p. 14582-14586, 1995.
Salkowski, C.A., Detore, G., McNally, R., Rooijen N.v., Vogel, S.N., Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccaride in vivo, The Journal of Immunology, p. 905-912, 1996.
Peng, HB., Spiecker, M., Liao, J.K., Inducible nitric oxide: An autoregulatory feedback inhibitor of vascular inflammation, The Journal of Immunology, p. 1970-1976, 1998.
Gumina, R.J., Schultz, J.E., Yao, Z., Kenny D., Warltier, D.C., Newman, P.J., Gross, G.J., Antibody to platelet/endothelial cell adhesion molecule-1 reduces myocardial infarct size on a rat model of ischemia-reperfusion injury, Circulation, V.94, N.12, p. 3327-3333, 1996.
Levine, L., Morgan, R.A., Lewis, R.A., Austen, K.F., Clark, D.A., Marfat, A., Corey, E.J., Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis,Proc. Natl. Acad. Sci. USA, V.78, N.12, p. 7692-7696, 1981.
Rodionova, N.P., Shapot, V.S., Ribonucleic acids of the endoplasmic reticulum of animal cells, Biochim. Biophys. Acta., N.129, p. 206-209, 1966.
Lukacs, G.L., Kapus, A., Nanda, A., Romanek, R., Grinstein, S., Proton conductance of the plasma membrane: properties, regulation and functional role, American Physiological Society, p. C3-C14, 1993.
Moscat, J., Moreno, F., Herrero, C., Iglesias, S., Garcia-Barreno, P., Arachidonic acid releasing systems in pig aorta endothelial cells, Biochemical and Biophysical Research Communications, V.139, N.3, p. 1098-1103, 1986.
Zavodnik, I.B., PiletSkaya, T.P., Acid-induced Haemolysis of Human Erythrocytes, Belarussian Acad. Sci., p. 1106-1112, 1997.
Anderson, J.L., Carlquist, J.F., Muhlestein, J.B., Home, B.D., Elmer, S.P., Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction, J Am Coll Cardiol, V.32, N.1, p. 35-41, 1998 (abstract).
Arnet, U.A., McMillan, A., Dinerman, J.L., Ballermann, B., Lowenstein, C.J., Regulation of endothelial nitric-oxide synthase during hypoxia, J Biol Chem, V.271, N.25, p. 15069-15073, 1996 (abstract).
Arvinte, T., Cudd, A., Schultz, B., Nicolau, C., Low-pH association of proteins with the membranes of intact red blood cells. II. Studies of the mechanism, Biochem Biophys Acta, V.981, N.1, p. 61-8, 1989 (abstract).
Balligand, J.L., Kobzik, L., Han, X., Kaye, D.M., Belhassen, L., O'Hara, D.S., Kelly, R.A., Smith, T.W., Michel, T., Nitric oxide dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthas
Biocell Laboratories
Li Q. Janice
Westerman Hattori Daniels & Adrian LLP
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