Method of promoting the differentiation of staminal cells

Details Method of promoting the differentiation of staminal cells Method of promoting the differentiation of staminal cells

2004-03-19

2009-12-29

Gamett, Daniel C (Department: 1647)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S365000

Reexamination Certificate

active

07638330

ABSTRACT:
A method is described by which stem cells are induced to differentiate into cardiomycocytes; the method comprises exposure for a length of time and at efficacious quantities of a protein of the EGF-CFC family or its derivatives having at least the EGE and CFC domains; or to differentiate into neuronal cells, comprising the exposure to Cripto protein inhibitors. Compositions are described for therapeutic use in treating heart disorders, comprising a therapeutically efficacious quantity of a protein or its derivatives having at least the EGF and CFC domains of a protein of the EGF-CFC family.

REFERENCES:
patent: WO 01/68814 (2001-09-01), None
patent: WO 02/26941 (2002-04-01), None
patent: WO 2004/053084 (2004-06-01), None
PCT International Search Report for Minchiotti, et al., Int'l Application No. PCT/IT04/000133, Filed Mar. 19, 2004, Dated Sep. 2, 2004.
Piccolo, et al., “The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals”, Nature, vol. 397, No. 6721, pp. 707-710 (1999).
Parisi, et al., “Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells”, Journal of Cell Biology, vol. 163, No. 2, pp. 303-314 (2003).
Adamson, et al., “Cripto: A tumor growth factor and more”, Journal of Cellular Physiology, vol. 190, No. 3, pp. 267-278 (2002).
Xu, et al., “Specific arrest of cardioegensis in cultured embryonic stem cells lacking Cripto-1”, Developmental Biology, vol. 196, No. 2, pp. 237-247 (1998).
Baldassarre, et al, “Transfection with a Cripto anti-sense plasmid suppresses endogenous Cripto expression and inhibits transformation in a human embryonal carcinoma cell line”, International Journal of Cancer, vol. 66, No. 4, pp. 538-543 (1996).

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