Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2011-07-05
2011-07-05
Chernyshev, Olga N (Department: 1649)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S192100, C424S194100, C514S002600, C514S018700
Reexamination Certificate
active
07972601
ABSTRACT:
Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the disclosure includes site-specific delivery of the antioxidant to the endoplasmic reticulum (ER) to reverse incorrect disulfide binding of the protein neuroligin. Also disclosed is a method of targeting the antioxidant to neuroligin by using the calcium binding or other recognition site of neuroligin to bind the antioxidant. The antioxidant can be cysteamine linked to a molecule which binds to a binding site.
REFERENCES:
Jamain, Stephane et al., Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism; Nature Genetics, May 2003, pp. 27-29, vol. 34.
Jamain, Stephane, et al., Mutations of the X-linked neuroligins NLGN3 and NLGN4 are associated with autism, Am. J. Med. Genetics, 2003, 122B, 1, p. 20.
Ylisaukko-Oja, Tero et al., Sequence and haplotype analysis of neuroligins NLGN1, NLGN3 and NLGN4 in Finnish autism families, Am. J. Med. Genetics, 2003, 122B, 1 pp. 75-76.
Comoletti Davide
Flynn Robyn
Jennings Lori
Taylor Palmer
Baker, Jr. Joseph R.
Chernyshev Olga N
Gavrilovich Dodd & Lindsey LLP
The Regents of the University of California
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