Method of promoting bone growth with hyaluronic acid and growth

Details Method of promoting bone growth with hyaluronic acid and growth Method of promoting bone growth with hyaluronic acid and growth

1997-03-05

1999-08-24

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 2, 514 62, 536 53, 530350, A61K 31715

Patent

active

059424990

ABSTRACT:
A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10.sup.-6 to 100 mg/ml.

REFERENCES:
patent: 4394370 (1983-07-01), Jeffries
patent: 4409332 (1983-10-01), Jeffries
patent: 4472840 (1984-09-01), Jeffries
patent: 5013714 (1991-05-01), Lindstrom et al.
patent: 5030457 (1991-07-01), Ng et al.
patent: 5100668 (1992-03-01), Edelman et al.
patent: 5128326 (1992-07-01), Balazs et al.
patent: 5130418 (1992-07-01), Thompson
patent: 5143662 (1992-09-01), Chesterfield et al.
patent: 5158934 (1992-10-01), Ammann et al.
patent: 5202311 (1993-04-01), Folkman et al.
patent: 5206023 (1993-04-01), Hunziker
patent: 5217954 (1993-06-01), Foster et al.
patent: 5266683 (1993-11-01), Oppermann et al.
patent: 5294446 (1994-03-01), Schlameus et al.
patent: 5302397 (1994-04-01), Amsden et al.
patent: 5318957 (1994-06-01), Cid et al.
patent: 5344644 (1994-09-01), Igari et al.
patent: 5348941 (1994-09-01), Middaugh et al.
patent: 5354557 (1994-10-01), Oppermann et al.
patent: 5356629 (1994-10-01), Sander et al.
patent: 5366505 (1994-11-01), Farber
patent: 5366964 (1994-11-01), Lindstrom et al.
patent: 5368858 (1994-11-01), Hunziker
patent: 5368859 (1994-11-01), Dunn et al.
patent: 5387673 (1995-02-01), Seddon et al.
patent: 5399352 (1995-03-01), Hanson
patent: 5399583 (1995-03-01), Levy et al.
patent: 5409896 (1995-04-01), Ammann et al.
patent: 5416071 (1995-05-01), Igari et al.
patent: 5422340 (1995-06-01), Ammann et al.
patent: 5425769 (1995-06-01), Snyders, Jr.
patent: 5427778 (1995-06-01), Finkenaur et al.
patent: 5428006 (1995-06-01), Bechgaard et al.
patent: 5442053 (1995-08-01), della Valle et al.
patent: 5464440 (1995-11-01), Johansson
patent: 5470829 (1995-11-01), Prisell et al.
patent: 5482929 (1996-01-01), Funkunaga et al.
Noda et al., 1994 "In VivoStimulation of bone formation by Transforming Growth Factor--.beta.," Endicrinology124:2991-4.
Pouyani and Prestwich, 1994, "Biotinylated Hyaluronic Acid: A New Tool for Probing Hyaluronate-Receptor Interactions,"Bioconjugate Chem.5:370-2.
A.A. Pilla, et al., "Non-Invasive Low-Intensity Pulsed Ultrasound Accelerates Bone Healing in the Rabbit", Journal of Orthopaedic Trauma, (1990) 4:246-253.
S. Jingushi, et al., "Acidic Fibroblast Growth Factor (aFGF) Injections Stimulates Cartrilage Enlargement and Inhibits Cartilage Gene Expression in Rat Fracture Healing", Journal of Orthopaedic Trauma, (1990) 8:364-371.
Hiroshi Kawaguchi, et al., "Stimulation of Fracture Repair by Recombinant Human Basic Fibroblast Growth Factor in Normal and Streptozotocin-Diabetic Rats," Endicrinology, (1994) 135:774-781.
Urist, Marshall, "Bone: Formation by Autoinduction," Science 12, vol. 150, No. 3698, pp.893-899, Nov. 1965.
Reddi et al., "Introduction and maintenance of new bone formation by growth and differentiation factors," Annales Chirurgiae et Gynacologiae, vol. 77, pp.189-192, 1998.
Wiltfang et al., "Ectopic bone formation with the help of growth factor bFGF," Journal of Cranio-Maxillofacial Surgery, vol.24, No.5, pp.300-304, Oct. 1996.
Wozney, "Bone Morphogenetic Proteins," Progress in Growth Factor Research, vol.1, pp. 267-280, 1989.

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