Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1996-01-29
1998-04-07
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
424423, 424425, 424448, 435193, 514953, 514965, 530399, A61K 3845, A61K 3827, A61F 200, A61F 1302
Patent
active
057361320
ABSTRACT:
A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
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Aeschlimann Daniel
Hunziker Ernst B.
Juergensen Kay
Orthogene, Inc.
Slobodyansky Elizabeth
Wax Robert A.
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