Method of proliferating natural killer cells with IL-16

Details Method of proliferating natural killer cells with IL-16 Method of proliferating natural killer cells with IL-16

1996-08-23

1999-07-06

Naff, David M.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435325, 4353723, 435386, 424 937, C12N 500, C12N 506

Patent

active

059197005

ABSTRACT:
The invention relates to a method of stimulating the proliferation of natural killer cells with in vitro IL-16. A mixed lymphocyte cell population which contains natural killer cells can be nylon wool-purified, and cultured in the presence of an effective amount of IL-16 to stimulate the proliferation of natural killer cells. Effective concentrations of IL-16 which enhance the proliferation of natural killer cells range from 1 ng/ml to 1000 ng/ml. Both the full length IL-16 protein or the naturally occurring carboxy terminal-truncated form of IL-16 are suitable for stimulating the proliferation of the natural killer cells. The IL-16 induced proliferation results in at least a five-fold enrichment of natural killer cells, and the natural killer cells can be subsequently isolated from the mixed lymphocyte culture.

REFERENCES:
patent: 4604377 (1986-08-01), Fernandes et al.
patent: 4840934 (1989-06-01), Anderson
patent: 4908433 (1990-03-01), Mertelsmann et al.
patent: 5082657 (1992-01-01), Ranson
patent: 5418192 (1995-05-01), Borden et al.
B. Korant., et al., #23 259 J. Biol. Chem. 14835-14839 (1984).
D. Blomstrom, et al., #19 261 J. Biol. Chem. 8811-8816 (1986).
N. Reich, et al., 84 P.N.A.S. USA 6394-9398 (Sept. 1987).
A Haas, et al., 262 #23 J. Biol. Chem. 11315-11323 (1987).
E. Knight, et al., 263 #10 J. Biol. Chem. 4520-4522 (1988).
E. Knight, Jr., et al., 8 J. Interf. Res., Supp. 1, p. S4 (1988). #1-7 Abs.
N. Feltham, et al., 9 J. Interf. Res. 493-507 (1989).
H. Ziegler-Heitbrock, et al., 72 #1 JNCI 23-28 (Jan. 1984).
H. Ziegler-Heitbrock, et al., 46 Can. Res. 5947-5952 (Nov. 1986).
R. Philip, et al., 323 Nature 86-89 (Sep. 1986).
J. Nissen-Meyer, et al., 47 Can. Res. 2251-2258 (May 1987).
E. Borden, 54 #11 Cancer 2770-2776 (Dec. 1984). Supplement.
E. Borden, Interferons And Cancer: How The Promise Is Being Kept, "Interferons", vol. 5, Acad. Press 43-83 (1984). Ed. I. Gresser.
G. Antonelli, et al. "Generation of a Soluble IFN-Gamma Inducer by Oxidation of Galactose Residues on Macrophages" Cell. Immun. 94:440-446 (1985).
Y. Ozaki, et al. 144#3 Biochem. Biophys. Res. Commun. 1147-1153 (May 1987).
M. Julius, et al., 3 Eur. J. Immunol. 645-649 (1973).
M. Edelstein, et al., 143#9 J. Immunol. 2969-2973 (Nov. 1989).
J. Carlin, et al., 9 J. IFN Res. 167-173 (1989).
J. Carlin, et al., 139#7 J. Immunol. 2414-2418 (Oct. 1987).
J. Carlin, et al., 9 J. IFN Res. 329-337 (1989).
R. Devos, et al., 10#8 Nuc. Acids Res. 2487-2501 (1982).
J. Vilcek, "The Importance Of Having Gamma," in Interferon 1982, vol. 4, pp. 129-154 Academic Press (1982). Ed. I. Gresser.
Knight, Jr., et al., 263#10 J. Biol. Chem. 4520-4522 (Apr. 1988).
Recht, et al., 147#8 J. Immunol. 2617-2623 (Oct. 1991).
D'Cunha, et al., Abstract, J. Immunol. Ther. (Oct. 1992). vol. ?.
L. Moretta, et al., 55 Adv. in Immun. 341-381 (1994).
S. Rosenberg, Chapter 4 "Adoptive Immunotherapy of Cancer Using Lymphkine Activated Killer Cells and Recombinant Interleukin-2" in Important Advances in Oncology, Ed. DeVita, et al., Lippencott, Philadelphia, Pennsylvania pp. 55-91 (1986).
S. Rosenberg, et al., 313#23 The New Eng. J. of Med. 1485-1492 (1985).
L. Svedersky, et al., 133#2 J. Immunol. 714-718 (Aug. 1984).
L. Lanier, et al., 45 FASEB 2823-2828 (1986).
R. Foa, et al., 51 Can. Res. 964-968 (Feb. 1991).
R. Dillman, et al., 9#7 J. Clin. Oncol. 1233-1240 (Jul. 1991).

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