Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-09-16
2008-09-16
Myers, Carla (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S023500, C536S024310
Reexamination Certificate
active
11052344
ABSTRACT:
Provided are methods for prognostic prediction of metastasis. The method comprises identifying the presence or absence of a fragile site FRA12E on chromosome 12q24 at the SMRT gene locus. The presence of FRA12E in an individual can be determined in cell samples obtained from the individual by hybridization techniques such as fluorescence in situ hybridization techniques. The presence of this fragile site at this locus is indicative of higher likelihood of metastasis than if the fragile site is absent. Also provided are kits for the determination of likelihood of metastasis.
REFERENCES:
NCBI Database, National Center for Biotechnology Information, National Library of Medicine, NIH (Bethesda, MD, USA). GenBank Accession No. AC048340, Apr. 3, 2003.
NCBI Database, National Center for Biotechnology Information, National Library of Medicine, NIH (Bethesda, MD, USA). GenBank Accession No. AC027706, May 2, 2000.
NCBI Database, National Center for Biotechnology Information, National Library of Medicine, NIH (Bethesda, MD, USA). GenBank Accession No. AC068837, Jul. 13, 2000.
NCBI Database, National Center for Biotechnology Information, National Library of Medicine, NIH (Bethesda, MD, USA). GenBank Accession No. AC025685, May 6, 2000.
WO 03/106645 A2 (ISIS Pharmaceuticals, Inc.) Dec. 24, 2003, pp. 5-6.
Amarose et al.,A Heritable fragile 12q24.13 segregating in a family with the fragile X chromosome, Hum Genet, 1987, pp. 4-6.
Mimori, et al.,Cancer-specific chromosome alterations in the constitutive fragile region FRA3B, Proc. Natl. Acad. Sci. USA, Jun. 1999, Medical Sciences, vol 96, pp. 7456-7461.
Menin, et al.,Anomalous Transcripts and Allelic Deletions of the FHIT Gene in Human Esophageal Cancer, Cancer Genet Cytogenet, 2000, vol. 119, pp. 56-61.
Voiculescu, et al.,Homozygous condition for a BrdU-requiring fragile site on chromosome 12, Hum Genet, 1991, pp. 416-417.
Sutherland,Heritable Fragile Sites on Human Chromosomes I. Factors Affecting Expression in Lymphocyte Culture, Am J Hum Genet, 1979, vol. 31, pp. 125-135.
Jiang, et al.,Genomic organization and refined mapping of the human nuclear corepressor2(NCOR2)/silencing mediator of retinoid and thyroid hormone receptor(SMRT)gene on chromosome 12q24.3, Cytogenet Cell Genet, 2001, vol. 92, pp. 217-220.
Alcock, et al.; Analysis of Colorectal Tumor Progression by Microdissection and Comparative Genomic Hybridization; Genes, Chromosomes & Cancer, vol. 37, No. 4, Aug. 2003; XP-002453927; pp. 369-380.
Bova, et al.; Physical Mapping of Chromosome 8p22 Markers and Their Homozygous Deletion in a Metastatic Prostate Cancer; Genomics, vol. 35, No. 1, 1996; XP-002453929; pp. 46-54.
Coignet, et al.; Alteration of SMRT Tumor Suppressor Function in Transformed Non-Hodgkin Lymphomas; Blood, vol. 98, No. 11 Part 1, Nov. 16, 2001; XP-000808550; p. 760a and 43rdAnnual Meeting of the American Society of Hematology, Part 1; Orlando, FL; Dec. 7-11, 2001; ISSN: 0006-4971.
Dohna, et al.; Adrenocortical Carcinoma Is Characterized by a High Frequency of Chromosomal Gains and High-Level Amplifications; Genes, Chromosomes & Cancer, vol. 28, No. 2, Jun. 2000; XP-002453928; pp. 145-152.
Muzny, et al.;Homo sapiens12 BAC RP11-408I18 (Roswell Park Cancer Institute Human BAC Library) complete sequence; Mar. 27, 2003; XP-002453967; 64 pages.
Muzny, et al.;Homo sapiens12 BAC RP11-30G17 (Roswell Park Cancer Institute Human BAC Library) complete sequence; Mar. 27, 2003; XP-002453968; 6 pages.
Health Research , Inc.
Hodgson & Russ LLP
Myers Carla
LandOfFree
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