Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1993-09-15
1996-08-06
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424431, 424432, 424433, 5147723, 514841, 514843, 514967, A61F 606, A61F 1302, A61F 616, A61K 4730
Patent
active
055431500
ABSTRACT:
The present invention teaches that relatively low levels of serum progesterone, 1 to 6 ng/ml, may be used to prevent endometrial cancer. The vaginal delivery of progesterone using a cross-linked polycarboxylic polymer produces this low serum progesterone level while also providing the full secretory transformation of the endometrium, indicating the efficacy of the progesterone. Such low levels of serum progesterone will decrease the risk of breast cancer experienced by women undergoing hormone replacement therapy ("HRT") and minimize the potential of other undesirable progesterone associated side effects.
REFERENCES:
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Bologna William J.
Levine Howard L.
Azpuru Carlos
Blackman Scott H.
Columbia Laboratories, Inc.
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