Method of production of sustained-release preparation

Details Method of production of sustained-release preparation Method of production of sustained-release preparation

1996-08-29

2000-04-04

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, 42840224, A61K 916, A61K 4734

Patent

active

060458305

ABSTRACT:
A method of production of sustained-release microcapsules that comprises obtaining microcapsules comprising a bioactive substance that are encapsulated with a biodegradable polymer, and thermally drying the obtained microcapsules at a temperature not lower than the glass transition temperature of the biodegradable polymer for about 24 to about 120 hours to produce the sustained-release microcapsules comprising, relative to the weight of the sustained-release microcapsule, not less than 60% (w/w) of the biodegradable polymer, possessing pharmaceutical characteristics clinically excellent in that a bioactive substance is released at constant rate over a very long period of time from just after administration with dramatically suppressed initial release of the bioactive substance in excess just after administration and with minimum remaining organic solvent.

REFERENCES:
Keipert et al., "Antiglaumakotosaaltige Ophthalmika Mit Prolongierter Wirkung Aug Basis Makromolekularer Hilfsstoffe", Die Pharmazie, vol. 45, No. 8, (1990), pp. 594-595.

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