Method of producing tablets, tablets produced thereby, and metho

Details Method of producing tablets, tablets produced thereby, and metho Method of producing tablets, tablets produced thereby, and metho

1991-12-27

1993-08-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424464, 424465, 424474, 424480, 514960, 514891, A61K 914

Patent

active

052346960

ABSTRACT:
Dietetic formulations for oral use are described, made up of tablets formed from dense granules of mixtures of keto- or hydroxy-amino acid analogs, possibly coated by protective films, which are dissolved in the gastrointestinal juices. The process for obtaining dense granules includes a coordinated increase in pressure being maintained for a substantial period of time and subsequent tableting and possible coating by immersion or spraying of the granular material.

REFERENCES:
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patent: 4296127 (1981-10-01), Walser
patent: 4320146 (1982-03-01), Walser
patent: 4352814 (1982-10-01), Walser
patent: 4897270 (1990-01-01), Deutsch et al.
patent: 4908214 (1990-03-01), Bobee et al.
patent: 4957938 (1990-09-01), Anderson et al.
patent: 5137732 (1992-08-01), Buehler et al.
Walser, M., Ketoacids in the Treatment of Uremia, Clinical Nephrology, vol. 3, pp. 180-186 (1975).
Bergstram, J., et al., Metabolic Studies with Keto Acids in Uremia, The American Journal of Clinical Nutrition, vol. 31, pp. 1761-1766 (Oct. 1978).
Heiland, A., Evaluation of Essential Amino Acids and Keto Acids in Uremic Patients on Low-Protein Diet, The American Journal of Clinical Nutrition, 1784-1792 vol. 31, pp. (Oct. 1978).
Frohling, P. T., et al., Conservative Treatment with Ketoacid and Amino Acid Supplemented Low-Protein Diets in Chronic Renal Failure, vol. 33, pp. 1667-1673 (Jul. 1980).
Chronicled Sales Aid for Ketosteril.RTM. Tablets. Dated May 1984-Fresenious AG Bad Homburg, Germany 3 pages.
Search Report--from H. Z. Stone to J. Weis dated Nov. 26, 1990 24 pages.

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