Method of producing sustained-release microcapsules

Details Method of producing sustained-release microcapsules Method of producing sustained-release microcapsules

1995-11-27

1996-11-19

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424489, 424501, 424502, 514963, 264 41, 264 43, 264 433, 264 47, 428402, 4284022, 42840221, A61K 948, A61K 914, A61K 950, B32B 516

Patent

active

055759874

ABSTRACT:
A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.

REFERENCES:
patent: 3956172 (1976-05-01), Saeki et al.
S. Keipert et al., "Antiglaumakotosahaltige Ophthalmika mit Prolongierter Wirkung auf Basis Makromolekularer Hilfsstoffe, Teil 3,"Die Pharmazie, vol. 45, No. 8, pp. 594-595 (Jul. 1990).

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