Method of producing sugar chain using human G4 polypeptide

Details Method of producing sugar chain using human G4 polypeptide Method of producing sugar chain using human G4 polypeptide

2011-07-05

2011-07-05

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S097000, C435S193000

Reexamination Certificate

active

07972815

ABSTRACT:
The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyl transferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.

REFERENCES:
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patent: 98/44112 (1998-10-01), None
patent: 00/15826 (2000-03-01), None
patent: 01/85177 (2001-11-01), None
Zhou, et al., “Homo sapiensbeta-1,3-N-acetylglucosaminyltransferase mrRNA, complete cds”, XP-002205662, GenBank Accession No. AF092051 (Jan. 1999).
Di Virgillio, et al., “Enzymatic synthesis of natural and C-13 enriched linear poly-N-acetyllactosamines as ligands for galectin-1”, Glycobiology, vol. 9, No. 4 (1999), 353-364.
Zhou, et al., “A Beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to . . . ”, PNAS, vol. 96 (1999), 406-411.
Sasaki, et al., “Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis”, PNAS, vol. 94 (1997), 14294-14299.
Almeida, et al., “A Family of Human b-4-Galactosyltransferases. Cloning and Expression of Two Novel UDP-Galactose: b-N-Acetylglucosamine b-1,4-Galactosyltranferases . . . ”, J. Biol. Chem., vol. 272, No. 51 (1997), 31979-31991.
Schwientek, et al., “Cloning of a Novel Member of the UDP-Galactose: beta-N-Acetylglucosamine beta1,4-Galactosyltransferase Family . . . ”, J. Biol. Chem., vol. 273, No. 45 (1998), 29331-29340.

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