Method of producing RNA viruses from cDNA

Details Method of producing RNA viruses from cDNA Method of producing RNA viruses from cDNA

1995-06-01

1997-11-04

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4352351, 4351721, 4351723, 435 9151, 536 2372, 4242171, 935 77, C12N 704

Patent

active

056839014

ABSTRACT:
The present invention relates to methods for producing RNA virus cDNA, methods for producing viable, RNA virus and viable, RNA virus produced by those methods. The invention also related to a novel RNA virus cDNA, recombinant DNA molecules containing that cDNA and hosts transformed with those recombinant cDNA molecules. This invention further related to novel methods for screening for variants of a strain 3 poliovirus. This invention also related to methods for increasing the attenuation of a strain poliovirus.

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