Method of producing (R)-2-amino-1-phenylethanol and opticaly act

Details Method of producing (R)-2-amino-1-phenylethanol and opticaly act Method of producing (R)-2-amino-1-phenylethanol and opticaly act

1997-04-22

1998-12-08

Saucier, Sandra E..

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435106, 435129, 435280, C12P 1304, C12P 1300, C12P 1302, C12P 4100

Patent

active

058467920

ABSTRACT:
Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.

REFERENCES:
Richard J. Ulevitch et al., "Susdies of the Reactions of Sustituted D,L-Erthro-.beta.-Phenylserines with Lamb Liver Serine Hydroxymethylase. Effects of Substituents Upon the Dealdolization step". Biochemistry, vol. 16, No. 24, pp. 5355-5363, (1977).

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