Method of producing plasminogen activator

Details Method of producing plasminogen activator Method of producing plasminogen activator

1979-04-23

1980-11-04

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435215, C12N 972, C12N 948

Patent

active

042321247

ABSTRACT:
Production of plasminogen activator from human diploid lung cells through cultivation in an aqueous nutrient medium containing an inducer of activator production.
Lactalbumin hydrolysate is an active inducer, and is used in 0.1-1.0% w/v concentration in the medium.

REFERENCES:
patent: 3128228 (1964-04-01), Michl
patent: 3904480 (1975-09-01), Hull et al.
patent: 3930945 (1976-01-01), Lewis
Bernick et al., The Journal of Clinical Investigation vol. 48 (1969) pp. 1740-1753.
Barlow et al. "Production of Plasminogen Activator by Tissue Culture" in Proteases and Biological Control, Cold Spring Harbor Conference on Cell Proliferation vol. 2, 1975 pp. 325-331.

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