Method of producing plasma fractions free of side-effects using

Details Method of producing plasma fractions free of side-effects using Method of producing plasma fractions free of side-effects using

1982-05-05

1983-06-14

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, C07G 700

Patent

active

043882323

ABSTRACT:
In a method of producing plasma fractions free of side-effects by purification and step-wise enrichment of plasma proteins in the presence of calcium-binding anticoagulants, also fast reactive (avid) antithrombin is present, wherein a concentration of the fast reacting (avid) antithrombin of 0.05 to 50 units per ml of the respective solution is maintained during all fractionation process steps.

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Kirk-Othmer, Encyclopedia of Chem. Technology pp. 556-583 (1948).
Kowalski et al., "Heparin and the Inactivation of Thrombin by Anti-Thrombin III," Thrombosis Research pp. 387-397 (1979).
Chem. Abstracts, vol. 84, Nr. 7, Feb. 16, 1976, Abstract No. 40350e, p. 188, Columbus, Ohio, U.S., J. S. Rosenberg et al., "Inhibition of Human Factor IXa by Human Antithrombin", J. Biol. Chem. 1975, 250 (23) 8883-3.
Chem. Abstracts, vol. 89, Nr. 7, Aug. 14, 1978, Abstract No. 55381t p. 213, Columbus, Ohio, U.S., S. Chandra et al., "Large Scale".

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