Method of producing peptides using baculovirus vectors in cultur

Details Method of producing peptides using baculovirus vectors in cultur Method of producing peptides using baculovirus vectors in cultur

1991-01-16

1992-05-05

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4351723, 435 6951, 4352351, C12P 2100, C12N 1500, C12N 1520, C12N 1534

Patent

active

051107295

ABSTRACT:
Recombinant Bombyx mori nuclear polyhedrosis viruses having, in the polyhedral protein-encoding structural gene portion of the Bombyx mori nuclear polyhedrosis virus DNA (BmNPV DNA), a structural gene for a desired protein as joined to the whole of or a part of the polyhedral protein-encoding structural gene with or without interposition of a linker base sequence are provided.
By propagating the above viruses in silkworm-derived cells or silkworms, fused proteins of a desired protein and the whole of or a part of the polyhedral protein as joined together with or without interposition of a linking amino acid or peptide are produced. The desired proteins can be obtained from the fused proteins by cleavage or decomposition at the linking site.

REFERENCES:
patent: 4745051 (1988-05-01), Smith et al.
Morishita et al., J. Biochem., 109, 36-44, (1991).
Miller, (1982), in Genet. Eng. in Euk., pp. 89-97.
Rohrmann et al., (1981), J. Mol. Evol., 17, 329-333.
Pennock et al., (1984), Mol. Cell. Biol., 4:399-406.
S. Maeda, "Characteristics of Human Interferon-Alpha Produced by a Baculovirus Vector in the Silkworm, Bombyx mori", Proc. Japan Acad., vol. 60, No. 10, 423-426, (1984).
G. Smith, "Production of Human Beta Interferon in Insect Cells Infected with a Baciluvirus Expression Vector", Molecular and Cellular Biology, vol. 13, No. 12, 2516-2165, (1983).
R. Matthews, "Classification and Nomenclature of Viruses. Third Report of the International Committee on Taxonomy and Viruses", S. Karger, Basel, 170-171, (1979).

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