Method of producing optically active tert-leucinol and its use

Details Method of producing optically active tert-leucinol and its use Method of producing optically active tert-leucinol and its use

1996-02-21

1998-03-03

Lambkin, Deborah

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564303, 564503, C07C20988, C07C21508, C07B 5700

Patent

active

057236674

ABSTRACT:
A method of producing optically active tert-leucinol (formula I) of high enantiomeric purity ##STR1## by converting racemic (RS)-tert-leucinol into a diastereomeric salt pair by reaction with an optically active acid, removing the salt pair from solution by fractionated crystallization and separating therefrom the optically active acid to release the optically active tert-leucinol from the salt. The optically active acid used is an N-acylated tert-leucine of general formula VIII: ##STR2## in which R can be hydrogen or an alkyl-, arylalkyl- or aryl group with up to 20 C atoms and * signifies a chirality center.

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