Method of producing N.sup.1 -(2-tetrahydrofuryl)-5-fluorouracil

Details Method of producing N.sup.1 -(2-tetrahydrofuryl)-5-fluorouracil Method of producing N.sup.1 -(2-tetrahydrofuryl)-5-fluorouracil

1976-12-16

1978-08-29

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40504

Patent

active

041105370

ABSTRACT:
N.sup.1 -(2-tetrahydrofuryl)-5-fluorouracil is produced in high yield by reacting 5-fluorouracil with 2,3-dihydrofuran in the presence of trimethylsilyl chloride and a tertiary amine and treating the resultant mixture with an aqueous alkaline solution.

REFERENCES:
brossmer et al., Chemical Abstracts, vol. 78 (1973), 58343r.

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