Method of producing monoclonal antibodies to oncofetal protein

Details Method of producing monoclonal antibodies to oncofetal protein Method of producing monoclonal antibodies to oncofetal protein

1995-05-26

1997-07-22

Housel, James C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4351722, 435330, 435344, 53038825, 5303871, 5303881, 5303888, C12P 2108, C12N 512, C07K 1618, C07K 1630

Patent

active

056503008

ABSTRACT:
The present invention provides a low cost, less toxic, anti-cancer immunotherapy which enhances the host's immune system ability to destroy or contain cancers, and also provides a diagnostic test for cancer. Specifically, the present invention provides monoclonal antibodies specific for, that is, specifically bind, oncofetal protein (OFP), a cancer cell product. Tumors treated with a single dose of the monoclonal antibodies against OFP are markedly reduced in size, and leukemic populations of cells treated with a single does of monoclonal antibodies against OFP are significantly decreased in number. Since the monoclonal antibodies of the present invention do not bind to tumor cells, the monoclonal antibody treatment overcomes the disadvantages associated with tumor cell targeting. Monoclonal antibodies to OFP offer a simple and inexpensive agent for use as a primary or adjuvant therapy against a wide variety of cancers and tumors in humans and other animals. The monoclonal antibodies against OFP are also employed to detect cancer in animal, including human patients.

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Steve Runge's thesis "Characterization of an Oncofetal Protein (OFP) and Cloning of its cDNA" pp. 76-113, Cataloged at Ohio State University, Jul. 30, 1992.
Oredipe, O.A., et al. Carcinogenesis, 10(12): 2175-2181, Dec., 1989.
Abstract #1711, Schumm, D.E., Proc. Ann. Meet. Am.Assoc. Ca. Res. 33:A1711, Mar. 1992.
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Abstract #1669, Runge, S.W., et al., "Characterization of an Oncofetal Protein (OFP) and Cloning of Its cDNA", Proc. Am. Assoc., Ca. Res. 32: Mar. 1991.
Abstract #7502, Runge, S.W., et al. "Characterization of an Oncofetal Protein (OFP) and Cloning of Its cDNA", 75th Annual Meeting of Assoc. of Biochem. and Mol. Biol. FASEB, Apr. 1991.
Runge, S., et al. "Development and Use of Monoclonal Antibodies Against an Oncofetal Protein Associated with Carcinogenesis and Tumorgenesis" Immunlogical Investigation, 20(3):269-286 (1991).
Stromberg, Paul C., et al. "Expression of an Oncofetal Protein (OFP) in Rat and Human Leukemia Cells", Leukemia Research, vol. 15, pp. 427-433 (1991).

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