Method of producing monoclonal anti-idiotype antibody

Details Method of producing monoclonal anti-idiotype antibody Method of producing monoclonal anti-idiotype antibody

1984-09-25

1987-10-13

Marantz, Sidney

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 7, 43524027, 436531, 436548, 436804, 530387, 530412, 935 93, 935103, 935110, C12N 500, G01N 33577

Patent

active

046998802

ABSTRACT:
A method for determining the presence of an antigen in a liquid sample. The method includes incubating the sample with an antibody which specifically binds an epitope on the antigen in the presence of a given quantity of an anti-idiotype antibody which specifically binds an epitope on the hypervariable region of the antibody. Also, a method of producing a monoclonal anti-idiotype antibody by fusing lymphocytes from an animal in which a tumor capable of secreting idiotype antibodies has been grown, with myeloma cells.

REFERENCES:
patent: 4238195 (1980-12-01), Boguslaski
patent: 4513088 (1985-04-01), Levy
patent: 4536479 (1985-08-01), Vander-Mallie
"Contemporary Topics in Molecular Immunology", vol. 8, F. P. Inman et al., eds., Chapt. by J. Urbain entitled Idiotypic Regulation in Immune Networks, p. 119 only, Plenum Press, New York, 1981.
Suzan, M. et al., Molecular Immunology, 19(8), 1051-1062 (1982).

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