Method of producing L-serine by fermentation

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

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43525232, 4352521, 435193, 435195, C12P 1306, C12N 914, C12N 120, C12N 112

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active

060371544

ABSTRACT:
L-serine is produced by cultivating in a medium a coryneform bacterium having L-serine productivity in which an activity of at least one of phosphoserine phosphatase and phosphoserine transaminase is enhanced, preferably, further having introduced therein a gene coding for D-3-phosophoglycerate dehydrogenase in which feedback inhibition by L-serine is desensitized, allowing L-serine to accumulate in the medium, and collecting the L-serine from the medium.

REFERENCES:
Fell et al., Biochem. J., 256, 97-101, Oct. 1988.

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