Method of producing L-serine

Details Method of producing L-serine Method of producing L-serine

1985-02-05

1988-11-01

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435106, 435193, 435849, 4351721, C12P 1306, C12P 1304, C12N 910, C12N 1500

Patent

active

047820217

ABSTRACT:
This invention is a method of producing L-serine by causing glycine to react with formaldehyde by using the culture solution or the microbe cells of a microorganism belonging to the genus Escherichia, having the ability of producing serine hydroxymethyltransferase and not having the practical ability of producing L-serine from glycine alone or enzymatic matter obtained through the treatment of the above culture solution or microbe cells.
In this invention, the yield of L-serine can be increased either by carrying out the reaction while maintaining aldehyde concentration at 20 mM or below or by using microbe cells of the aforementioned microorganism after they are caused to contact glycine.

REFERENCES:
patent: 3755081 (1973-08-01), Yamade
Schirch, "Senne Hydroxy methyltransferase", Advances in Enzymology, vol. 53 (1982) John Wiley & Sons, N.Y. pp. 83-111.
Ishiwata, et al., "L-Senne Production", Chem Absts, vol. 103, No. 23 (Dec. 1985) p. 579 absts No. 194952a.

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