Method of producing L-lysine

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S115000

Reexamination Certificate

active

07846698

ABSTRACT:
The L-lysine-producing ability and the L-lysine-producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihydrodipicolinate reductase, DNA coding for a dihydrodipicolinate synthase, DNA coding for a diaminopimelate decarboxylase, and DNA coding for a diaminopimelate dehydrogenase.

REFERENCES:
patent: 5688671 (1997-11-01), Sugimoto et al.
patent: 5804414 (1998-09-01), Moriya et al.
patent: 6004773 (1999-12-01), Araki et al.
patent: 0 435 132 (1991-07-01), None
patent: 0699759 (1996-03-01), None
patent: 0 733 710 (1996-09-01), None
patent: 0 811 682 (1997-12-01), None
patent: 94/25605 (1994-11-01), None
Ngo et al., Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
U.S. Appl. No. 10/009,777, filed Dec. 17, 2001, Sugimoto et al.
U.S. Appl. No. 10/019,284, filed Jan. 2, 2002, Sugimoto et al.
U.S. Appl. No. 10/148,898, filed Jun. 19, 2002, Sugimoto et al.
Kalinowski J. et al., “Genetic and biochemical analysis of the aspartokinase fromCorynebacterium glutamicum”, Molecular Microbiology, 1991, vol. 5, pp. 1197-1204.
Bonnassie, S., et al., “Nucleotide sequence of thedapAgene fromCorynebacterium glutamicum,” Nucleic Acids Res. 1990;18(21):6421.
Pisabarro, A., et al., “A Cluster of Three Genes (dapA, orf2, anddapB) ofBrevibacterium lactofermentumEncodes Dihydrodipicolinate Synthase, Dihydrodipicolinate Reductase, and a Third Polypeptide of Unknown Function,” J. Bacteriol. 1993;175(9):2743-2749.
Canadian Office Action for Canadian Appl. No. 2,224,058, dated Sep. 7, 2005.
Cremer, J., et al., “Regulation of Enzymes of Lysine Biosynthesis inCorynebacterium glutamicum,” J. Gen. Microbiol. 1988;134:3221-3229.
Jetten, M. S. M., et al., “Recent Advances in the Physiology and Genetics of Amino Acid-Producing Bacteria,” Critical Rev. Biotechnol. 1995;15(1):73-103.
Office Communication from the European Patent Office for EP Patent App. No. 96916305.4 (Mar. 25, 2008) with English translation.
Applied and Environmental Microbiology, vol. 57, No. 6 (1991), Hermann Sahm, et al., see p. 1746-1752.
JP, 7-7557, A (Mitsubishi Petrochemical Co., Ltd.), Mar. 20, 1995.
Nucleic Acids Res., vol. 15, No. 9, (1987), Kazumi Araki, et al., see p. 3917.
Molecular Microbiology, vol. 4, No. 11, (1990), A. J. Sinskey, et al., see p. 1819-1830.
Molecular and General Genetics, vol. 212, No. 1, (1988), A. J. Sinskey, et al., see p. 112-119.
Rudinger (1976) Characteristics of the amino acids as components of a peptide hormone sequence. In: Peptide Hormones. Ed. J.A. Parsons. University Park Press, Baltimore, MD. pp. 1-7.
Ngo et al. (1994) Computational complexity, protein structure prediction, and the Ilevinthal paradox. In: The Protein Folding Problem and Tertiary Structure Prediction. Eds. Merz et al. Birkhauser et al. Boston, MA. pp. 491-495.
Thornton et al. (1995) Protein Engineering: Editorial Overview. Current Opinion in Biotechnology 6(4): 367-369.
Wallace (1993) Understanding cytochrome c function: engineering protein structure by semisynthesis. The FASEB Journal 7:505-515.
Eikmanns, B. J., et al., “Molecular aspects of lysine, threonine, and isoleucine biosynthesis inCorynebacterium glutamicum,” Antonie van Leeuwenhoek 1993;64:145-163.
Communication Pursuant to Rule 114(2) EPC from EP Patent App. No. 96916305.4 (Oct. 30, 2009).
Graves, L. M., et al., “Aspartokinase III, a New Isozyme inBacillus subtilis168,” J. Bacteroil. 1990;172(1):218-223.
Hanel, F., et al., “Control of the Aspartokinase ofStreptomyces Nourseiand Its AEC-Resistant Mutants,” Biotechnol Lett. 1985;7(8):557-562.
Hernando-Rico, V., et al., “Structure of the ask-asd operon and formation of aspartokinase subunits in the cephamycin producer ‘Amycolatopsis lactamdurans’ ,” Microbiol. 2001;147:1547-1555.
Third Party Observation from European Patent App. No. 96916305.4 (Sep. 30, 2010) with English translation.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of producing L-lysine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of producing L-lysine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of producing L-lysine will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4157619

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.