Method of producing L-glutamic acid by fermentation

Details Method of producing L-glutamic acid by fermentation Method of producing L-glutamic acid by fermentation

1994-12-05

1996-02-20

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435106, 435110, 43525232, 435843, C12P 1314, C12P 1318

Patent

active

054928184

ABSTRACT:
The present invention provides a method of producing L-glutamic acid by fermentation, comprising the steps of
culturing a mutant of an L-glutamic acid-producing microorganism of the genus Brevibacterium or Corynebacterium which has lower .alpha.-ketoglutaric acid dehydrogenase activity compared with the wild strains from which said mutant is derived, in a liquid nutrient culture medium containing biotin at a concentration of 10 to 1000 .mu.g/l without adding a biotin activity-suppressing substance thereto;
producing and accumulating L-glutamic acid in the culture solution; and
recovering L-glutamic acid from said culture solution.
According to the method of the present invention, it is possible to industrially produce L-glutamic acid by fermentation in a more economical and efficient manner.

REFERENCES:
patent: 4411991 (1983-10-01), Hirakawa et al.
Liebl et al., International Journal of Systematic Bacteriology, vol. 41, pp. 255-260 (1991).
Agric. Biol. Chem., vol. 44, No. 8, (1980), pp. 1897-1904, Isamu Shiio et al, "Presence and Regulation of .alpha.-Ketoglutarate . . . in a Glutamate-Producing Bacterium, Brevibacterium flavum".
Agric. Biol. Chem., vol. 46, No. 2, (1982), pp. 493-500, Isamu Shiio et al, "Glutamate Metabolism in a Glutamate-producing Bacterium, Brevibacterium flavum".

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