Method of producing iturin A and antifungal agent for profound m

Details Method of producing iturin A and antifungal agent for profound m Method of producing iturin A and antifungal agent for profound m

1994-09-29

1995-11-28

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 712, 435 713, 435167, 530317, 530321, C12P 2104, A61K 3812

Patent

active

054708273

ABSTRACT:
The present invention is a method of producing iturin A, in which cells of Bacillus amyloliquefaciens are incubated and iturin A is collected from the culture. It also relates to an antifungal agent for profound mycosis, containing iturin A as the active ingredient. Heretofore, there have been known few medicines effective against profound mycosis, but iturin A may be an effective antifungal agent for profound mycosis.

REFERENCES:
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Isoagi et al; Structures of B-Amino Acids in Antibiotics Iturin A, Tetrahedron Letters, vol. 23, No. 30, pp. 3065-3068; 1982.
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Isogai et al, Structures of B-Amino Acids in Antibiotics Iturin A, Tetrahedron Letters, vol. 23, No. 30, pp. 3065-3068, 1982.
Delcambe et al, L'Iturine, Nouvel Antibiotique Produit Par Un Bacillus Subtilis, C. R. Soc. Biol., vol. 144, pp. 1431-1434, 24, Jun. 1950.
Clairbois et al, D'Essais Cliniques Et Biologiques Sur L'Iturine, Antifunique Nouveau, Arch. Belges. Derm. Et. Syph., vol. 14, pp. 63-82, 1985.

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