Method of producing iturin A and antifungal agent for profound m

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide

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435 712, 4352525, 435832, 514 11, 530317, C12P 2104

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active

054948096

ABSTRACT:
The present invention is a method of producing iturin A, in which cells of Bacillus amyloliquefaciens are incubated and iturin A is collected from the culture. It also relates to an antifungal agent for profound mycosis, containing iturin A as the active ingredient. Heretofore, there have been known few medicines effective against profound mycosis, but iturin A may be an effective antifungal agent for profound mycosis.

REFERENCES:
patent: 4508825 (1985-04-01), Kim et al.
Hatada; Plant Pathogenic Germ Sporulation Inhibitor, Patent Abstracts of Japan, The Patent Office Japanese Government, vol. 11, No. 159; May 22, 1987.
Hatada; Production of Factor For Suppressing Sporulation of Phytopathogenic Fungus, Patent Abstracts of Japan the Patent Office Japanese Government, vol. 11, No. 159; May 22, 1987.
Isogai et al.; Structures Of B-Amino Acids In Antibiotics Iturin A, Tetrahedron Letters, vol. 23, No. 30, pp. 3065-3068; 1982.
Nippon Byori Gakkai Kaishi, Opportunistic Fungus Infection, Tr. Soc. Pathol. Jpn., vol. 74, pp. 61-91, 1985.
Medoff et al., Antifungal Agents Useful in Therapy of Systemic Fungal Infections, Ann. Rev. Pharmacol. Toxicol., vol. 23, pp. 303-330, 1983.
Isogai et al., Structures of B-Amino Acids in Antibiotics Iturin A, Tetrahedron Letters, vol. 23, No. 30, pp. 3065-3068, 1982.
Delcambe et al., L'Iturine, Nouvel Antibiotique Produit Par Un Bacillus Subtilis, C. R. Soc. Biol., vol. 144, pp. 1431-1434. 24 Jun. 1950.
Clairbois et al., D'Essais Cliniques et Biologiques sur L'Iturine, Antifungique Nouveau, Arch. Belges. Derm. Et. Syph., vol. 14, pp. 63-82, 1985.

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