Method of producing intravenously injectable gamma globulin and

Details Method of producing intravenously injectable gamma globulin and Method of producing intravenously injectable gamma globulin and

1976-05-21

1978-06-06

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 86, 424 87, 424177, 424101, A23J 106

Patent

active

040936066

ABSTRACT:
A process is provided for the preparation of a gamma globulin suitable for intravenous administration from the readily available Fraction II or II + III plasma protein paste. The Fraction II or II + III paste is extracted with water at a pH of 4.8 - 6.5 and impurities are fractionally precipitated by addition of polyethylene glycol to 4% of wt./vol. and then 5% wt./vol. The desired gamma globulin is then precipitated at a pH 8.0 by addition of polyethylene glycol to 12% wt./vol.

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