Method of producing intravenously injectable gamma globulin

Details Method of producing intravenously injectable gamma globulin Method of producing intravenously injectable gamma globulin

1976-12-03

1978-11-07

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, A23J 106, A61K 3706

Patent

active

041245768

ABSTRACT:
An improved process is provided for the preparation of a gamma globulin suitable for intravenous administration from the readily available Fraction II or II + III plasma protein paste or from the corresponding fractions originating from placental extracts. The Fraction II or II + III paste is extracted with water at a pH of 4.9 to 6.0 and impurities are fractionally precipitated by addition of polyethylene glycol to 4% of wt./vol. and then 6% vol. ethanol. The desired gamma globulin is then precipitated at a pH 8.0 by addition of polyethylene glycol to 12% wt./vol.

REFERENCES:
patent: 3763135 (1973-10-01), Shanbrom et al.
patent: 3808189 (1974-04-01), Breuer

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