Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-06-07
1998-08-04
Kemmerer, Elizabeth C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530324, 530344, 530399, 530408, 530412, 435 695, 4351723, C07K 114, C07K 14435, C07K 1465, C12N 1512
Patent
active
057895473
ABSTRACT:
The present invention provides a novel method for refolding insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3(IGFBP-3). The method involves mixing of IGF-I and IGFBP-3 together in a cofolding reaction. The inventive cofolding method results in substantially higher yields of correctly folded protein for both molecules and alters the kinetics of refolding. The method includes the production of correctly folded IGF-I, IGFBP-3, and/or IGF-I/IGFBP-3 complex.
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Ogawa Yasushi
Sommer Andreas
Tao Peggy
Celtrix Pharmaceuticals Inc.
Kemmerer Elizabeth C.
Romeo David S.
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