Method of producing immune response by administering polymeric c

Details Method of producing immune response by administering polymeric c Method of producing immune response by administering polymeric c

1980-10-01

1982-01-05

Cacciapaglia, Jr., Frank

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 81, 424 85, 525328, 525378, A61K 3174, A61K 3178, A61K 3900, C08F 830

Patent

active

043094139

ABSTRACT:
The disclosure relates to a method of producing an immune response in a warm-blooded animal comprising administering to said animal from about 0.1 to about 100 mg/Kg of body weight of a composition selected from the group consisting of a copolymer of olefin monomer and polycarboxylic anhydride having an average molecular weight of from about 300 to about 1500 in which said copolymer is derivatized to contain (a) half-amide, half-carboxyl acid groups and (b) imide groups in which said imide groups comprise from about 5% to about 40% by weight of said derivatized groups, and the pharmaceutically acceptable cationic salt derivatives of said derivatized copolymers.

REFERENCES:
patent: 2883287 (1959-04-01), Kosmin et al.
patent: 3157595 (1964-11-01), Johnson et al.
patent: 4255537 (1981-03-01), Fields et al.
Regelson, Advances in Cancer Research, 11 (1968), pp. 223-226 & 240-241.
Regelson et al., Nature, 186: 778-780, (Jun. 1960).
Regelson, Polymeric Science and Technology 2: 161-168, (1973).
Breslow, Pure and Applied Chemistry, 46: 103-113, (1976).
Hodnett et al., J. Med. Chem. 17 (12) 1335-1337, (1974).

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